Chargé de recherche (CNRS)
Email: vlebrun@unistra.fr
Phone: +33 (0)3 68 85 14 26
Educational record:
Since 2017 Chargé de Recherche (CNRS, section 16) in P. Faller’s group (Biometals & Biological Chemistry, UMR 7177).
2014-2017 Postdoctoral fellow in the group of Thomas Ward, University of Basel, Switzerland.
2011-2014 PhD under the supervision of Olivier Sénèque and Jean-Marc Latour, University of Grenoble Alpes. “Zinc fingers and oxidative stress: reactivity towards singlet oxygen and hypochlorous acid”.
2011 Master degree in BioOrganic and BioInorganic Chemistry, University of Grenoble Alpes.
Research Interest:
metallopeptide: design & synthesis, characterization, reactivity ; peptide self-assembly ; artificial metalloenzymes ;
Publications :
Burning amyloid-beta with a near infrared photosensitizer. (Preview in CHEM) Lebrun, V., Faller, P, Chem, 2018, 4, 663-665.
Artificial Metalloenzymes: Reaction Scope and Optimization Strategies. Schwizer, F., Okamoto, Y., Heinisch, T., Gu, Y., Pellizzoni, M.M., Lebrun, V., Reuter, R., Köhler, V., Lewis, J.C. and Ward, T.R., Chem. Rev., 2018, 118, 141-231.
Towards Cellular Activation of an Artificial Metalloenzyme: Development of an Artificial Zymogen. Lebrun, V.*, Chimia, 2017, 71, 199-201.
Upregulation of an Artificial Zymogen by Proteolysis. Liu, Z.*, Lebrun, V.*, Kitanosono, T., Mallin, H., Köhler, V., Häussinger, D., Hilvert, D., Kobayashi, S., and Ward, T.R., Angew. Chem., Int. Ed., 2016, 55, 11567-11590. (*: co-first authors)
Anion-π Enzymes. Cotelle, Y., Lebrun, V., Sakai, N., Ward, T.R., and Matile, S., ACS Cent. Sci.,2016, 2, 388-393.
Interfacing functional systems. Cotelle, Y., Chuard, N., Lascano, S., Lebrun, V., Wehlauch, R., Bohni, N., Lörcher, S., Postupalenko, V., Reddy, S.T., Meier, W., Palivan, C., Gademann, K., Ward, T. R., Matile, S., Chimia Int. J. Chem., 2016, 70, 418-423.
Near diffusion-controlled reaction of a Zn(Cys)4zinc finger with hypochlorous acid. Lebrun, V., Ravanat, J.-L., Latour, J.-M., and Sénèque, O., Chem. Sci.,2016, 7, 5508-5516.
Reactivity of a Zn(Cys)2(His)2Zinc Finger with Singlet Oxygen: Oxidation Directed toward Cysteines but not Histidines. Lebrun, V., Tron, A., Lebrun, C., Latour, J.-M., McClenaghan, N.D., and Sénèque, O., Chem. Eur. J.,2015, 21, 14002-14010.
Efficient Oxidation and Destabilization of Zn(Cys)4Zinc Fingers by Singlet Oxygen. Lebrun V., Tron A., Scarpantonio L., Lebrun C., Ravanat J.-L., Latour J.-M., McClenaghan N. D., Sénèque O., Angew. Chem. Int. Ed.,2014, 53, 9365-9368.
Catalytic Zinc Complexes for Phosphate Diester Hydrolysis. Tirel E. Y., Bellamy Z., Adams H., Lebrun V., Duarte F., Williams N. H., Angew. Chem. Int. Ed., 2014, 53, 8246-8250.
On the Design of Zinc-Finger Models with Cyclic Peptides Bearing a Linear Tail. Jacques A., Mettra B., Lebrun V., Latour J-M., Sénèque O., Chem. Eur. J.,2013, 12, 3921-3931.
Cyclic Peptides Bearing a Side-Chain tail : a Tool to Model the Structure and Reactivity of Protein Zinc Sites. Sénèque O., Bourlès E., Lebrun V., Bonnet E., Dumy P., Latour J-M., Angew. Chem. Int. Ed., 2008, 47, 6888-6891.