2019


A Molecular Theranostic Agents for Photodynamic Therapy (PDT) and Magnetic Resonance Imaging (MRI)

Sébastien Jenni, Angélique Sour*

Inorganics, 7(1), 10 (2019) – DOI: 10.1039/C8MT00274F


2018


The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(II) from albumin. Implications for copper uptake by Ctr1

Ewelina Stefaniak, Dawid Płonka, Simon C. Drew, Karolina Bossak-Ahmad, Kathryn L. Haas, M. Jake Pushie, Peter Faller, Nina E. Wezynfeld*, Wojciech Bal*

Metallomics, 10, 1723-1727 (2018) – DOI: 10.1039/C8MT00274F


Cu transfer from amyloid-β4–16 to metallothionein-3: the role of the neurotransmitter glutamate and metallothionein-3 Zn(II)-load states

Alice Santoro, Nina Ewa Wezynfeld, Ewelina Stefaniak, Adam Pomorski, Dawid Płonka, Artur Krężel* Wojciech Bal*, Peter Faller*

Chem. Commun. 54, 12634-12637 (2018) – DOI: 10.1039/C8CC06221H

 

 


Low catalytic activity of the Cu(II)-binding motif (Xxx-Zzz-His; ATCUN) in reactive oxygen species production and inhibition by the Cu(I)-chelator BCS

Alice Santoro, Gulshan Walke, Bertrand Vileno, Prasad P. Kulkarni, Laurent Raibaut, Peter Faller*

Chem. Commun. 54, 11945-11948 (2018) – DOI: 10.1039/C8CC06040A


Cu and Zn interaction with amyloid peptides: From fascinating chemistry to debated pathological relevance

Elena Atrián-Blasco, Paulina Gonzalez, Alice Santoro, Bruno Alies, Peter Faller, Christelle Hureau *

Coord. Chem. Rev. 371, 38-55 (2018) – DOI:  10.1016/j.ccr.2018.04.007

 

 


Burning Amyloid-β with a Near-Infrared Photosensitizer

Lebrun, V. & Faller. P.  (Preview, not peer reviewed)

CHEM, 4, 663–665 (2018) – DOI: 10.1016/j.chempr.2018.03.019

 

Toc 2018


Ascorbate oxidation by Cu(Amyloid-β) complexes: determination of the intrinsic rate as function of alterations in the peptide sequence reveals key residues for ROS production

Atrián-Blasco E, Del Barrio M, Faller P.* Hureau C.*

Anal Chem. 90, 5909-5915 (2018) – DOI: 10.1021/acs.analchem.8b00740

 

Toc 2018


N-terminal Cu Binding Motifs Xxx-Zzz-His (ATCUN) and Xxx-His and their derivatives: Chemistry, Biology and Medicinal Applications

Gonzalez P, Bossak K, Stefaniak E, Hureau C, Raibaut L, Bal W.*, Faller, P.*

Chem. Eur. J.  24, 8029-8041 (2018) – DOI: 10.1002/chem.201705398

 

Toc 2018


Aβ/drug interactions from computer simulations and cell-based assays

Nguyen PH, Del Castillo-Frias MP, Berthoumieux O, Faller P, Doig AJ, Derreumaux P.*

J Alzheimers Dis. – DOI: 10.3233/JAD-179902.(2018)


2017


Cu(II)-binding to the peptide Ala-His-His, a chimera of the canonical Cu(II)-binding motifs Xxx-His and Xxx-Zzz-His (ATCUN)

Gonzalez P, Vileno B, Bossak K, El Khoury Y, Hellwig P, Bal W, Hureau C*, Faller P.*

Inorg. Chem. 56, 14870-14879 (2017) – DOI: 10.1021/acs.inorgchem.7b01996

 

Toc 2017


Chemistry of Mammalian Metallothioneins and their Interaction with Amyloidogenic Peptides and Proteins

Atrián-Blasco E, Santoro A, Pountney DL, Meloni G, Hureau C, Faller P.*

Chem. Soc. Rev., 46, 7683-7693 (2017) – DOI: 10.1039/c7cs00448f

 

Toc 2017


Oxidative stress and the amyloid beta peptide in Alzheimer’s Disease

Cheignon C, Tomas M, Bonnefont-Rousselot D, Faller P, Hureau C, Collin F.*

Redox Biology, 14, 450-464 (2018) – DOI: 10.1016/j.redox.2017.10.014

 

Toc 2017


Cysteine and Glutathione trigger the Cu-Zn swap between Cu(II)-Amyloid-β4-16 peptide and Zn7-Metallothionein-3

Santoro A, Wezynfeld N. E., Vašák M, Bal W, Faller P.*

Chem. Comm., 53, 11634-11637 (2017) – DOI: 10.1039/c7cc06802f

 

 

Toc 2017

 

 

 

 

 

 


Why Is Research on Amyloid-β Failing to Give New Drugs for Alzheimer’s Disease? (Viewpoint)

Doig AJ, Del Castillo-Frias MP, Berthoumieu O, Tarus B, Nasica-Labouze J, Sterpone F, Nguyen PH, Hooper NM, Faller P, Derreumaux P.

ACS Chem Neurosci. ACS, 8, 1435-1437 (2017) – DOI: 10.1021/acschemneuro.7b00188

 

Toc 2017


Identification of key structural features of the elusive Cu-Aβ complex generating ROS in Alzheimer’s Disease

Cheignon C, Jones M, Atrián-Blasco E, Kieffer I, Faller P, Collin F, Hureau C.*

Chemical Science, 8, 5107-5118 (2017) – DOI: 10.1039/c7sc00809k

 

Toc 2017


Similarities and differences of copper and zinc cations binding to biological relevant peptides studied by vibrational spectroscopies

Schirer A, El Khoury Y, Faller P, Hellwig P.*

Biol. Inorg. Chem, 22, 581-589 (2017) – DOI: 10.1007/s00775-017-1449-0


Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies

Okita Y, Rcom-H’cheo-Gauthier AN, Goulding M, Chung RS, Faller P, Pountney DL.*

Front Neurosci. Apr 4;11:114. – DOI: 10.3389/fnins.2017.00114