2022


Graphical abstract: Development of Cu(ii)-specific peptide shuttles capable of preventing Cu–amyloid beta toxicity and importing bioavailable Cu into cells

Development of a Cu(II)-specific peptide shuttles capable of preventing Cu-Amyloid beta toxicity and importing bioavailable Cu into cells

Michael Okafor,   Paulina Gonzalez,   Pascale Ronot,   Islah El Masoudi,   Anne Boos,   Stéphane Ory,   Sylvette Chasserot-Golaz,   Stephane Gasman,   Laurent Raibaut,   Christelle Hureau*,   Nicolas Vitale*  and  Peter Faller*

Chem. Sci., accepted (2022) DOI10.1039/D2SC02593K


Why the Ala-His-His Peptide Is an Appropriate Scaffold to Remove and Redox Silence Copper Ions from the Alzheimer’s-Related Aβ Peptide

Paulina Gonzalez, Laurent Sabater, Emilie Mathieu, Peter Faller and Christelle Hureau*

Biomolecules, 12, 1327 (2022)


Copper-Catalyzed Glutathione Oxidation is Accelerated by the Anticancer Thiosemicarbazone Dp44mT and Further Boosted at Lower pH.

Falcone E, Ritacca AG, Hager S, Schueffl H, Vileno B, El Khoury Y, Hellwig P, Kowol CR, Heffeter P*, Sicilia E*, Faller P.*

J Am Chem Soc. 2022, 144, 14758-14768. DOI: 10.1021/jacs.2c05355 

 


Copper Induces Protein Aggregation, a Toxic Process Compensated by Molecular Chaperones.

Zuily L, Lahrach N, Fassler R, Genest O, Faller P, Sénèque O, Denis Y, Castanié-Cornet MP, Genevaux P, Jakob U, Reichmann D, Giudici-Orticoni MT, Ilbert M*.

mBio. 2022, 13, e0325121. DOI: 10.1128/mbio.03251-21


2021


Copper Imbalance in Alzheimer’s Disease and Its Link with the Amyloid Hypothesis: Towards a Combined Clinical, Chemical, and Genetic Etiology.

Squitti R*, Faller P, Hureau C, Granzotto A, White AR, Kepp KP.

J Alzheimers Dis. 2021 Jul 2. –DOI: 10.3233/JAD-201556.


A luminescent ATCUN peptide variant with enhanced properties for copper(II) sensing in biological media.

Falcone E, Vileno B, Hoang M, Raibaut L, Faller P*.

J Inorg Biochem. 221, 111478 (2021)- DOI: 10.1016/j.jinorgbio.2021.111478.


Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes and Amyotrophic Lateral Sclerosis 

Nguyen PH, Ramamoorthy A, Sahoo BR, Zheng J, Faller P, Straub JE, Dominguez L, Shea JE, Dokholyan NV, De Simone A, Ma B, Nussinov R, Najafi S, Ngo ST, Loquet A, Chiricotto M, Ganguly P, McCarty J, Li MS, Hall C, Wang Y, Miller Y, Melchionna S, Habenstein B, Timr S, Chen J, Hnath B, Strodel B, Kayed R, Lesné S, Wei G, Sterpone F, Doig AJ, Derreumaux P.

Chem. Rev.121, 2545-2647 (2021)- DOI:10.1021/acs.chemrev.0c01122

Reproducibility Problems of Amyloid-β Self-Assembly and How to Deal with them

Faller, P. * Hureau, C.*

Front Chem., 8, 611227 (2021)- DOI: 10.3389/fchem.2020.611227

 

 


Extracellular Cu2+ pools and their detection: from current knowledge to next-generation probes

Falcone, E.*, Okafor, M. Vitale, N., Raibaut L., Sour, A, Faller P.*

Coord. Chem. Rev. 433 213727 (2021)- DOI: 10.1016/j.ccr.2020.213727

 

 

 


2020


Copper-binding motifs Xxx-His or Xxx-Zzz-His (ATCUN) linked to an antimicrobial peptide: Cu-binding, antimicrobial activity and ROS production

Bouraguba, Merwan; Glattard, Elise; Naude, Maxime; Pelletier, Remi; Aisenbrey, Christopher; Bechinger, Burkhard; Raibaut, Laurent; Lebrun, Vincent* and Faller, Peter*

Journal of Inorganic Biochemistry (2020), 213, 111255- DOI: 10.1016/j.jinorgbio.2020.111255


How trimerization of CTR1 N-terminal model peptides tunes Cu-binding
and redox-chemistry

Galler, Thibaut; Lebrun, Vincent; Raibaut, Laurent; Faller, Peter; Wezynfeld, Nina E*

Chemical Communications  (2020), 56(81), 12194-12197- DOI: 10.1039/D0CC04693K

 

 


A terbium(iii) luminescent ATCUN-based peptide sensor for selective and reversible
detection 
of copper(ii) in biological media

Chemical communications (2020), 56 (35), 4797-4800. – DOI: 10.1039/D0CC01007C

 


The glutathione/metallothionein system challenges the design of 
efficient O2-activating Cu-complexes

Santoro A, Calvo JS, Peris-Díaz MD, Krężel A, Meloni G, Faller P*

Angewandte Chemie (2020), 59(20), 7830-7835. – DOI: 10.1002/anie.201916316

 

 


2019



Acrolein and Copper as Competitive Effectors of α-Synuclein

HOT Paper

Falcone E, Ahmed IMM, Oliveri V, Bellia* F, Vileno B, El Khoury Y, Hellwig P, Faller P*, Vecchio G

Chemistry, 26(8), 1871-1879 (2019)- DOI: 10.1002/chem.201904885

 

 


Reversible turn-on fluorescent Cu(II) sensors: rather dream than reality?

(Dalton Transactions HOT articles)

Enrico Falcone,  Angélique Sour,  Vincent Lebrun,  Gilles Ulrich,  Laurent Raibaut* and  Peter Faller*

Dalton Trans, 48, 14233-14237 (2019) – DOI: 10.1039/C9DT02864A

 



(Bio)Chemical strategies to modulate amyloid-βself-assembly

Ayala S, Genevaux P, Hureau C, Faller P.

ACS Chem Neurosci. 10, 3366-3374 (2019) – DOI: 10.1021/acschemneuro.9b00239

 

 

 

 


                     Switching on Endogenous Metal Binding Proteins in Parkinson’s Disease

                     Fleur A. McLeary, Alexandre N. Rcom-H’cheo-Gauthier, Michael Goulding,

                     Rowan A. W. Radford, Yuho Okita , Peter Faller, Roger S. Chung and Dean L. Pountney*

                     Cells. 8, E179, (2019) – DOI: 10.3390/cells8020179

 


Triggering Cu-coordination change in Cu(II)-Ala-His-His by external ligands

Chem. Commun., 55, 8110-8113 (2019)  – DOI: 10.1021/acs.inorgchem.9b00711

 

 


Copper-Targeting Approaches in Alzhzeimer’s Disease: How To Improve
the Fallouts obtained from in VItro Studies 

Charlène Esmieu, Djamila Guettas, Amandine Conte-Daban, Laurent Sabater, Peter Faller, and Christelle Hureau*

Inorg. Chem., 58 (20), 13509-13527 ( – DOI: 10.1021/acs.inorgchem.9b00711

 

 


Role of PTA in the prevention of Cu(amyloid-β) induced ROS formation and amyloid-β oligomerisation in the presence of Zn

Metallomics, 11, 1154-1161 (2019)   – DOI: 10.1021/acs.inorgchem.9b00711

 


Cu(II) Binding to the N-Terminal Model Peptide of the Human Ctr2 Transporter at
Lysosomal and Extracellular pH

Nina E. Wezynfeld,* Bertrand Vileno, and Peter Faller

Inorganic Chemistry, 58, 7488-7498 (2019)  – DOI: 10.1021/acs.inorgchem.9b00711

 

 

 


Reactivity of Cu(II)-, Zn(II)-, and Fe(II)-thiosemicarbazone complexes with glutathione and metallothionein: from stability to dissociation to transmetallation

Metallomics, 11, 994-1004 (2019) – DOI: 10.1039/C9MT00061E

 

 


   A Molecular Theranostic Agents for Photodynamic Therapy (PDT)
   and Magnetic Resonance Imaging (MRI)               

   Sébastien Jenni, Angélique Sour*

   Inorganics7(1), 10 (2019) – DOI: 10.1039/C8MT00274F

 

 

 

 


2018


The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(II)
from albumin. Implications for copper uptake by Ctr1

Ewelina Stefaniak, Dawid Płonka, Simon C. Drew, Karolina Bossak-Ahmad,
Kathryn L. Haas, M. Jake Pushie, Peter Faller, Nina E. Wezynfeld*, Wojciech Bal*

Metallomics, 10, 1723-1727 (2018) – DOI: 10.1039/C8MT00274F

 

 


                Cu transfer from amyloid-β4–16 to metallothionein-3 : the role of the
                neurotransmitter glutamate and metallothionein-3 Zn(II)-load states

                Alice Santoro, Nina Ewa Wezynfeld, Ewelina Stefaniak, Adam Pomorski, Dawid Płonka,
                Artur Krężel* Wojciech Bal*, Peter Faller*

                Chem. Commun. 54, 12634-12637 (2018) – DOI: 10.1039/C8CC06221H

 

 

 


Low catalytic activity of the Cu(II)-binding motif (Xxx-Zzz-His; ATCUN) in reactive oxygen species production and inhibition by the Cu(I)-chelator BCS

Alice Santoro, Gulshan Walke, Bertrand Vileno, Prasad P. Kulkarni, Laurent Raibaut,
Peter Faller*

Chem. Commun. 54, 11945-11948 (2018) – DOI: 10.1039/C8CC06040A

 

 


Cu and Zn interaction with amyloid peptides: From fascinating chemistry to debated pathological relevance

Elena Atrián-Blasco, Paulina Gonzalez, Alice Santoro, Bruno Alies, Peter Faller, Christelle Hureau *

Coord. Chem. Rev. 371, 38-55 (2018) – DOI:  10.1016/j.ccr.2018.04.007

 


Toc 2018Burning Amyloid-β with a Near-Infrared Photosensitizer

Lebrun, V. & Faller. P.  (Preview, not peer reviewed)

CHEM, 4, 663–665 (2018) – DOI: 10.1016/j.chempr.2018.03.019

 

 

 

 


Toc 2018Ascorbate oxidation by Cu(Amyloid-β) complexes: determination of the intrinsic rate as function of alterations in the peptide sequence reveals key residues for ROS production

Atrián-Blasco E, Del Barrio M, Faller P.* Hureau C.*

Anal Chem. 90, 5909-5915 (2018) – DOI: 10.1021/acs.analchem.8b00740

 

 


Toc 2018N-terminal Cu Binding Motifs Xxx-Zzz-His (ATCUN) and Xxx-His and their derivatives: Chemistry, Biology and Medicinal Applications

Gonzalez P, Bossak K, Stefaniak E, Hureau C, Raibaut L, Bal W.*, Faller, P.*

Chem. Eur. J.  24, 8029-8041 (2018) – DOI: 10.1002/chem.201705398

 

 

 


Aβ/drug interactions from computer simulations and cell-based assays

Nguyen PH, Del Castillo-Frias MP, Berthoumieux O, Faller P, Doig AJ, Derreumaux P.*

J Alzheimers Dis. – DOI: 10.3233/JAD-179902.(2018)


2017


Toc 2017Cu(II)-binding to the peptide Ala-His-His, a chimera of the canonical Cu(II)-binding motifs Xxx-His and Xxx-Zzz-His (ATCUN)

Gonzalez P, Vileno B, Bossak K, El Khoury Y, Hellwig P, Bal W, Hureau C*, Faller P.*

Inorg. Chem. 56, 14870-14879 (2017) – DOI: 10.1021/acs.inorgchem.7b01996

 

 

 

 

 

 


Toc 2017Chemistry of Mammalian Metallothioneins and their Interaction with Amyloidogenic Peptides and Proteins

Atrián-Blasco E, Santoro A, Pountney DL, Meloni G, Hureau C, Faller P.*

Chem. Soc. Rev., 46, 7683-7693 (2017) – DOI: 10.1039/c7cs00448f

 

 


Toc 2017Oxidative stress and the amyloid beta peptide in Alzheimer’s Disease

Cheignon C, Tomas M, Bonnefont-Rousselot D, Faller P, Hureau C, Collin F.*

Redox Biology, 14, 450-464 (2018) – DOI: 10.1016/j.redox.2017.10.014

 

 

 

 


Cysteine and Glutathione trigger the Cu-Zn swap between Cu(II)-Amyloid-β4-16 peptide and Zn7-Metallothionein-3Toc 2017

Santoro A, Wezynfeld N. E., Vašák M, Bal W, Faller P.*

Chem. Comm., 53, 11634-11637 (2017) – DOI: 10.1039/c7cc06802f

 

 

 

 


Toc 2017Why Is Research on Amyloid-β Failing to Give New Drugs for Alzheimer’s Disease? (Viewpoint)

Doig AJ, Del Castillo-Frias MP, Berthoumieu O, Tarus B, Nasica-Labouze J, Sterpone F, Nguyen PH, Hooper NM, Faller P, Derreumaux P.

ACS Chem Neurosci. ACS, 8, 1435-1437 (2017) – DOI: 10.1021/acschemneuro.7b00188

 

 

 


Toc 2017Identification of key structural features of the elusive Cu-Aβ complex generating ROS in Alzheimer’s Disease

Cheignon C, Jones M, Atrián-Blasco E, Kieffer I, Faller P, Collin F, Hureau C.*

Chemical Science, 8, 5107-5118 (2017) – DOI: 10.1039/c7sc00809k

 

 


Similarities and differences of copper and zinc cations binding to biological relevant peptides studied by vibrational spectroscopies

Schirer A, El Khoury Y, Faller P, Hellwig P.*

Biol. Inorg. Chem, 22, 581-589 (2017) – DOI: 10.1007/s00775-017-1449-0


Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies

Okita Y, Rcom-H’cheo-Gauthier AN, Goulding M, Chung RS, Faller P, Pountney DL.*

Front Neurosci. Apr 4;11:114. – DOI: 10.3389/fnins.2017.00114