Laurent Raibaut

Maître de Conférences – Assistant Professor (Université de Strasbourg)


Phone: +33 (0)3 68 85 14 26

Educational record:

Since 2016      Maître de Conférences/Assistant Professor in Pr. P. Faller’s group (Biometals & Biological Chemistry, University of Strasbourg).

2015-2014       Postdoctoral fellow in the group of  Dr. Olivier Sénèque, CEA-Grenoble, University of Grenoble Alpes.

2010-2013       PhD under the supervision of Dr. O.Melnyk “New native peptide ligation strategies for total chemical protein synthesis”,
University of Lille, Pasteur Institute of Lille.

2010                Master degree in BioOrganic chemistry, Ecole Nationale Supérieure de Chimie Paris Tech, France.

2010-2013       Engineer degree in organic chemistry, Ecole Nationale Supérieure de Chimie Clermont-Ferrand, France.

Research Interest:

Solid Phase Peptide Synthesis, Protein total synthesis, Native chemical Ligation, Metallopeptide, Fluorophore, Lanthanide


Bouraguba, M; Glattard, E; Naude, M; Pelletier, Ri; Aisenbrey, C; Bechinger, B; Raibaut, L; Lebrun, V; Faller, P; Copper-binding motifs Xxx-His or Xxx-Zzz-His (ATCUN) linked to an antimicrobial peptide: Cu-binding, antimicrobial activity and ROS production. Journal of Inorganic Biochemistry, 2020, 213, 111255.

Fremy, G; Raibaut, L; Cepeda, C; Sanson, M; Boujut, M; Seneque, O; A novel DOTA-like building block with a picolinate arm for the synthesis of lanthanide complex-peptide conjugates with improved luminescence properties. Journal of Inorganic Biochemistry, 2020, 213, 111257.

Cepeda, C ;  Raibaut, L ;  Fremy, G ;  Svetlana V., E ;  Romieu, A ;  Pécaut, J ;  Boturyn, D ;  Petoud, S ;  Sénèque, O; Using Native Chemical Ligation for Site‐specific Synthesis of Hetero‐bis‐lanthanide Peptide Conjugates: Application to Ratiometric Visible or Near‐infrared Detection of Zn2+, Chemistry A European Journal, 2020, 26(59), 13476-13483.

Falcone, E; Sour, A;  Lebrun, V;  Ulrich, G; Raibaut, L* and Faller, P*; Reversible turn-on fluorescent Cu(II) sensors: rather dream than reality? Dalton Trans, 201948, 14233-14237.

Santoro, A; Walke, G.; Vileno, B.; Kulkarni, P.; Raibaut, L.; Faller, P.; Low catalytic activity of the Cu(II)-binding motif (Xxx-Zzz-His; ATCUN) in reactive oxygen species production and inhibition by the Cu(I)-chelator BCS. Chem. Commun. 2018, 54, 11945-11948.

Gonzalez, P.; Bossak, K.; Stefaniak, E.; Hureau, C.; Raibaut, L.; Bal, W.; Faller, P.; N-terminal Cu Binding Motifs Xxx-Zzz-His (ATCUN) and Xxx-His and their derivatives: Chemistry, Biology and Medicinal Applications. Chem. Eur. J. 2018, 24, 8029-8041.

Isaac M, Raibaut L, Cepeda C, Roux A, Boturyn D, Eliseeva SV, Petoud S and Sénèque O, Luminescent zinc fingers: Zn-responsive neodymium near-infrared emission in water. Chem. Eur. Journal, 2017, 23 (46), 10992-10996.

Raibaut, L.; Vasseur, W.; Shimberg, G. D.; Saint-Pierre, C.; Ravanat, J.-L.; Michel, S. L. J.; Sénèque, O., Design of a synthetic luminescent probe from a biomolecule binding domain: selective detection of AU-rich mRNA sequences. Chem. Sci. 2017, 8, 1658-1664.

Raibaut, L.; Cargoët, M.; Ollivier, N.; Chang, Y. M.; Drobecq, H.; Boll, E.; Desmet, R.; Monbaliu, J.-C. M.; Melnyk, O., Accelerating chemoselective peptide bond formation using bis(2-selenylethyl)amido peptide selenoester surrogates. Chem. Sci. 2016, 7 (4), 2657-2665.

Raibaut, L.; Drobecq, H.; Melnyk, O., Selectively Activatable Latent Thiol and Selenolesters Simplify the Access to Cyclic or Branched Peptide Scaffolds. Organic Letters 2015, 17 (14), 3636-3639.

Raibaut, L., El Mahdi, O., and Melnyk, O., Solid Phase Protein Chemical Synthesis. Top Curr Chem 2014, 363, 103-154.

Desmet, R.; Pauzuolis, M.; Boll, E.; Drobecq, H.; Raibaut, L.; Melnyk, O., Synthesis of Unprotected Linear or CyclicO-Acyl Isopeptides in Water Using Bis(2-sulfanylethyl)amido Peptide Ligation. Organic Letters 2015, 17 (13), 3354-3357.

Simonneau, C.; Leclercq, B.; Mougel, A.; Adriaenssens, E.; Paquet, C.; Raibaut, L.; Ollivier, N.; Drobecq, H.; Marcoux, J.; Cianférani, S.; Tulasne, D.; De Jonge, H.; Melnyk, O.; Vicogne, Semi-synthesis of a HGF/SF kringle one (K1) domain scaffold generates a potent in vivo MET receptor agonist. J. Chem. Sci. 2015, 6, 2110-2121.

Boll, E.; Drobecq, H.; Ollivier, N.; Blanpain, A.; Raibaut, L.; Desmet, R.; Vicogne, J.; Melnyk, O., One-pot chemical synthesis of small ubiquitin-like modifier protein-peptide conjugates using bis(2-sulfanylethyl)amido peptide latent thioester surrogates. Nature Protocols 2015, 10 (2), 269-92.

Boll, E.; Ebran, J. P.; Drobecq, H.; El-Mahdi, O.; Raibaut, L.; Ollivier, N.; Melnyk, O., Access to large cyclic peptides by a one-pot two-Peptide segment ligation/cyclization process. Organic Letter 2015, 17 (1), 130-3.

Ollivier, N.; Blanpain, A.; Boll, E.; Raibaut, L.; Drobecq, H.; Melnyk, O., Selenopeptide transamidation and metathesis. Organic Letter 2014, 16 (15), 4032-5.

Boll, E.; Drobecq, H.; Ollivier, N.; Raibaut, L.; Desmet, R.; Vicogne, J.; Melnyk, O., A novel PEG-based solid support enables the synthesis of > 50 amino acids peptide thioesters and the total synthesis of a functional SUMO-1 peptide conjugate. Chemical Science 2014, 5 (5), 2017-22.

Ollivier, N.; Raibaut, L.; Blanpain, A.; Desmet, R.; Dheur, J.; Mhidia, R.; Boll, E.; Drobecq, H.; Pira, S. L.; Melnyk, O., Tidbits for the synthesis of bis(2-sulfanylethyl)amido (SEA) polystyrene resin, SEA peptides and peptide thioesters. Journal of Peptide Science 2014, 20 (2), 92-97.

Chassagne, P.; Raibaut, L.; Guerreiro, C.; Mulard, L. A., Concise synthesis of di- and trisaccharides related to the O-antigens from Shigella flexneri serotypes 6 and 6a, based on late stage mono-O-acetylation and/or site-selective oxidation. Tetrahedron 2013, 69 (48), 10337-50.

Raibaut, L.; Seeberger, P.; Melnyk, O., Bis(2-sulfanylethyl)amido Peptides Enable Native Chemical Ligation at Proline and Minimize Deletion Side-Product Formation. Organic Letters 2013, 15 (21), 5516-19.

Raibaut, L.; Adihou, H.; Desmet, R.; Delmas, A. F.; Aucagne, V.; Melnyk, O., Highly efficient solid phase synthesis of large polypeptides by iterative ligations of bis(2-sulfanylethyl)amido (SEA) peptide segments. Chemical Science 2013, 4 (10), 4061-66.

Raibaut, L.; Vicogne, J.; Leclercq, B.; Drobecq, H.; Desmet, R.; Melnyk, O., Total synthesis of biotinylated  N domain of human hepatocyte growth factor. Bioorganic & Medicinal Chemistry 2013, 21 (12), 3486-94.

Raibaut, L.; Ollivier, N.; Melnyk, O., Sequen4al na4ve pep4de liga4on strategies for total chemical protein synthesis. Chemical Society Reviews 2012, 41 (21), 7001-15.

Brevet « Procédé de synthèse de protéines» 16-FR1159348 du 17 oct. 2011
Oleg Melnyk, Laurent Raibaut, Vincent Aucagne, Agnès Delmas.

Brevet « Nouveau procédé de ligation native » 17-FR1252548 du 21 mars 2012
Oleg Melnyk, Laurent Raibaut, Nathalie Ollivier.