Chargée de recherche – Research Associate (CNRS)
Email: a.sour@unistra.fr
Phone: +33 (0)3 68 85 13 63

Professional experiences and research topics:

Since 2018     Research Associate at the University of Strasbourg in the group of Pr. P. Faller (Laboratoire de Biométaux et Chimie Biologique).

2010-2018     Research Associate at the University of Strasbourg in the group of Pr. V. Heitz.
Research field: contrast agents for MRI, porphyrin-based photosensitizers for PhotoDynamic Therapy.

Previous research fields in different universities:
molecular machines, contrast agents for MRI, photochemistry, spin crossover, dendrimers, organic and coordination chemistry.

1991-1994      PhD in Chemistry, University of Strasbourg (Supervisor : Dr. J.-P. Sauvage) Transfert d’électron et transfert d’énergie dans des systèmes dinucléaires à ligands pontants rigides.

Recent publications:

  1. “Diketopyrrolopyrrole−Porphyrin Conjugates with High Two−Photon Absorption and Singlet Oxygen Generation for Two−Photon Photodynamic Therapy” J. Schmitt, V. Heitz, A. Sour, F. Bolze, H. Ftouni, J.-F. Nicoud, L. Flamigni, B. Ventura, Angew. Chem. Int. Ed. 2015, 54, 169-173.
  2. “A Theranostic Agent Combining a Two-Photon-Absorbing Photosensitizer for Photodynamic Therapy And A Gadolinium(III) Complex for MRI Detection”, J. Schmitt, V. Heitz, A. Sour, F. Bolze, P. Kessler, L. Flamigni, B. Ventura, C. S. Bonnet , É. Tóth, Chem. Eur. J., 2016, 22, 2775-2786.
  3. “Four Gd(III) complexes appended to a porphyrin: a water-soluble molecular theranostic agent with remarkable relaxivity suited for MRI tracking of the photosensitizer”, A. Sour, S. Jenni, A. Orti-Suarez, J. Schmitt, V. Heitz, F. Bolze, P. Loureiro de Sousa, C. Po, C. S. Bonnet, A. Pallier, É. Tóth, B. Ventura, Inorg. Chem,2016, 55, 4545-4554.
  4. “π-extended diketopyrrolopyrrole-porphyrin arrays : one- and two-photon photophysical investigation and theoretical studies”, Md. M. Alam, F. Bolze, C. Daniel, F. Flamigni, C. Gourlaouen, V. Heitz, S. Jenni, J. Schmitt, A. Sour, B. Ventura, Phys. Chem. Chem. Phys. 2016, 18, 21954-21965.
  5. “π-extended porphyrin dimers as efficient near-infrared emitters and two-photon absorbers”, J. Schmitt, V. Heitz, S. Jenni, A. Sour, F. Bolze, B. Ventura, Supramolecular Chem. 2017, 29, 769-775.
  6. “Molecular photosensitizers for two-photon photodynamic therapy”, F. Bolze, S. Jenni, A. Sour, V. Heitz, Chem. Commun. 2017, 53, 12857-12877.
  7. “A porphyrin dimer-GdDOTA conjugate as a theranostic agent for one- and two-photon photodynamic therapy and MRI”, J. Schmitt, S. Jenni, A. Sour, V. Heitz, F. Bolze, A. Pallier, C. S. Bonnet , É. Tóth, B. Ventura, Bioconjugate Chem. 2018, 29, 3726-3738.
  8. “Molecular Theranostic Agents for Photodynamic Therapy (PDT) and Magnetic Resonance Imaging (MRI), S. Jenni, A. Sour, Inorganics, 2019, 7, 10.
  9. “Tumour-​targeting photosensitisers for one- and two-​photon activated photodynamic therapy“, S. Jenni, A. Sour,F. Bolze, B. Ventura, V. Heitz, Org. Biomol. Chem. 2019, 17, 6585-6594.
  10. “Reversible turn-on fluorescent Cu(II) sensors: rather dream than reality?“, E. Falcone, A. Sour, V. Lebrun, G. Ulrich, L. Raibaut, P. Faller, Dalton Trans. 2019, 48, 14233-14237.
  11. “Multifunctional cubic liquid crystalline nanoparticles for chemo- and photodynamic synergistic cancer therapy“, S. Jenni, G. Picci, M. Fornasier, M. Mamusa, J. Schmidt, Y. Talmon, A. Sour, V. Heitz, S. Murgia, C. Caltagirone, Photochem. Photobiol. Sciences. 2020, 19, 674-680.
  12. “Synthesis and in vitro studies of a Gd(DOTA)​-​porphyrin conjugate for combined MRI and photodynamic treatment“, S. Jenni, F. Bolze, C.S. Bonnet, A. Pallier, A. Sour, E. Toth, B. Ventura, V. Heitz, Inorg. Chem. 2020, 59, 14389-14398.
  13. “Extracellular Cu2+ pools and their detection: From current knowledge to next-generation probes“, E. Falcone, M. Okafor, N. Vitale, L. Raibaut, A. Sour, P. Faller, Coord. Chem. Rev. 2021, 433, 213727.
  14. “Derivatization of the Peptidic Xxx−Zzz−His Motif toward a Ligand with Attomolar Cu II Affinity under Maintaining High Selectivity and Fast Redox Silencing”, Katharina Zimmeter, Bertrand Vileno, Carlos Platas−Iglesias, Bharath Vinjamuri, Angélique Sour, Peter Faller, Inorganic Chemistry, 2023, 62, 9429−9439.
  15. “Impact of human serum albumin on CuII and ZnII complexation by ATSM (diacetyl−bis(N4−methyl thiosemicarbazone) and a water soluble analogue; Álvaro Martínez−Camarena, Angélique Sour, Peter Faller; Dalton Transactions, 2023, 52, 13758−13768.
  16. “Three in One: In Vitro and In Vivo Evaluation of Anticancer Activity of a Theranostic Agent that Combines Magnetic Resonance Imaging, Optical Bioimaging, and Photodynamic Therapy Capabilities”; Sarah Boumati, Angélique Sour, Valérie Heitz, Johanne Seguin, Gautier Beitz, Yusuke Kaga, Marta Jakubaszek, Johannes Karges, Gilles Gasser, Nathalie Mignet, Bich-Thuy Doan; ACS Applied Bio Materials, 2023. https://doi.org/ 10.1021/acsabm.3c00565t.