PUBLICATIONS

2024

When Metal Complexes Evolve, and a Minor Species Is the Most Active: the Case of Bis(Phenanthroline)Copper in the Catalysis of Glutathione Oxidation and Hydroxyl Radical Generation.

Falcone E, Vigna V, Schueffl H, Stellato F, Vileno B, Bouraguba M, Mazzone G, Proux O, Morante S, Heffeter P, Sicilia E, Faller P.

Angew Chem Int Ed Engl. e202414652 (2024) doi: 10.1002/anie.202414652

Fluorescent Peptides Sequester Redox Copper to Mitigate Oxidative Stress, Amyloid Toxicity, and Neuroinflammation

Mandal S, Suseela YV, Samanta S, Vileno B, Faller P, Govindaraju T.

ACS Med. Chem. Lett.15, 1376-1385 (2024). doi:10.1021/acsmedchemlett.4c00283

Quest for a stable Cu-ligand complex with a high catalytic activity to produce reactive oxygen species

Bouraguba M, Schmitt AM, Yelisetty VS, Vileno B, Melin F, Glattard E, Orvain C, Lebrun V, Raibaut L, Ilbert M, Bechinger B, Hellwig P, Gaiddon C, Sour A, Faller P.

Metallomics. 2024 May 2;16(5):mfae020. DOI: 10.1093/mtomcs/mfae020

Restoring cellular copper homeostasis in Alzheimer disease: a novel peptide shuttle is internalized by an ATP-dependent endocytosis pathway involving Rab5- and Rab14-endosomes

Okafor M, Champomier O, Raibaut L, Ozkan S, El Kholti N, Ory S, Chasserot-Golaz S, Gasman S, Hureau C, Faller P, Vitale N..

Front Mol Biosci. 2024 Apr 5;11:1355963.. DOI: 10.3389/fmolb.2024.1355963

Glutathione Protects other Cellular Thiols against Oxidation by Cu^II -Dp44mT.

Doumi I, Lang L, Vileno B, Deponte M, Faller P.

Chemistry. 2024 Feb 26:e202304212. DOI: 10.1002/chem.202304212

2023

Impact of human serum albumin on Cu^II and Zn^II complexation by ATSM (diacetyl-bis(N4-methylthiosemicarbazone)) and a water soluble analogue..

Martínez-Camarena Á, Sour A, Faller P.

Dalton Trans. 2023 Oct 3;52(38):13758-13768 DOI: 10.1039/d3dt02380j

Human serum albumin as a copper source for anticancer thiosemicarbazones.

Schaier M, Falcone E, Prstek T, Vileno B, Hager S, Keppler BK, Heffeter P, Koellensperger G, Faller P, Kowol CR.

Metallomics. 15 (2023), mfad046. DOI: 10.1093/mtomcs/mfad046

Revisiting the pro-oxidant activity of copper: interplay of ascorbate, cysteine, and glutathione.

Falcone E*, Stellato F, Vileno B, Bouraguba M, Lebrun V, Ilbert M, Morante S, Faller P.

Metallomics.15, mfad040 (2023). DOI: 10.1093/mtomcs/mfad040 .

Derivatization of the Peptidic Xxx-Zzz-His Motif toward a Ligand with Attomolar CuII Affinity under Maintaining High Selectivity and Fast Redox Silencing

Zimmeter K, Vileno B, Platas-Iglesias C, Vinjamuri B, Sour A*, Faller P.*

Inorg. Chem. 62, 9429-9439 (2023)DOI: 10.1021/acs.inorgchem.3c00480

Chasing the Elusive “In-Between” State of the Copper-Amyloidβ Complex by X-ray Absorption through Partial Thermal Relaxation after Photoreduction.

Falcone E., Nobili G., Okafor M., Proux O., Rossi G., Morante S., Faller P.* Stellato F.*

Angew. Chem. Int. Ed. 62, e202217791 (2023), DOI: 10.1002/anie.202217791

Dual Role of Glutathione as a Reducing Agent and Cu-Ligand Governs the ROS Production by Anticancer Cu-Thiosemicarbazone Complexes.

Ritacca A.G., Falcone E., Doumi I., Vileno B., Faller P.*, Sicilia E.*.

Inorg Chem. 62, 3957-3964 (2023) doi: 10.1021/acs.inorgchem.2c04392

Thermodynamics-based rules of thumb to evaluate the interaction of chelators and kinetically-labile metal ions in blood serum and plasma

Falcone E, Faller P.*

Dalton Trans. 52, 2197-2208 (2023) DOI:10.1039/d2dt03875g

2022

Graphical abstract: Development of Cu(ii)-specific peptide shuttles capable of preventing Cu–amyloid beta toxicity and importing bioavailable Cu into cells

Development of a Cu(II)-specific peptide shuttles capable of preventing Cu-Amyloid beta toxicity and importing bioavailable Cu into cells

Michael Okafor, Paulina Gonzalez, Pascale Ronot, Islah El Masoudi, Anne Boos, Stéphane Ory, Sylvette Chasserot-Golaz, Stephane Gasman, Laurent Raibaut, Christelle Hureau*, Nicolas Vitale* and Peter Faller*

Chem. Sci., 13, 11829-11840 (2022) DOI : 10.1039/D2SC02593K

Why the Ala-His-His Peptide Is an Appropriate Scaffold to Remove and Redox Silence Copper Ions from the Alzheimer’s-Related Aβ Peptide

Paulina Gonzalez, Laurent Sabater, Emilie Mathieu, Peter Faller and Christelle Hureau*

Biomolecules, 12, 1327 (2022)

Copper-Catalyzed Glutathione Oxidation is Accelerated by the Anticancer Thiosemicarbazone Dp44mT and Further Boosted at Lower pH.

Falcone E, Ritacca AG, Hager S, Schueffl H, Vileno B, El Khoury Y, Hellwig P, Kowol CR, Heffeter P*, Sicilia E*, Faller P.*

J Am Chem Soc. 2022, 144, 14758-14768. DOI: 10.1021/jacs.2c05355

Copper Induces Protein Aggregation, a Toxic Process Compensated by Molecular Chaperones.

Zuily L, Lahrach N, Fassler R, Genest O, Faller P, Sénèque O, Denis Y, Castanié-Cornet MP, Genevaux P, Jakob U, Reichmann D, Giudici-Orticoni MT, Ilbert M*.

mBio. 2022, 13, e0325121. DOI: 10.1128/mbio.03251-21

2021

Copper Imbalance in Alzheimer’s Disease and Its Link with the Amyloid Hypothesis: Towards a Combined Clinical, Chemical, and Genetic Etiology.

Squitti R*, Faller P, Hureau C, Granzotto A, White AR, Kepp KP.

J Alzheimers Dis. 2021 Jul 2. –DOI: 10.3233/JAD-201556.

A luminescent ATCUN peptide variant with enhanced properties for copper(II) sensing in biological media.

Falcone E, Vileno B, Hoang M, Raibaut L, Faller P*.

J Inorg Biochem. 221, 111478 (2021)- DOI: 10.1016/j.jinorgbio.2021.111478.

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes and Amyotrophic Lateral Sclerosis

Nguyen PH, Ramamoorthy A, Sahoo BR, Zheng J, Faller P, Straub JE, Dominguez L, Shea JE, Dokholyan NV, De Simone A, Ma B, Nussinov R, Najafi S, Ngo ST, Loquet A, Chiricotto M, Ganguly P, McCarty J, Li MS, Hall C, Wang Y, Miller Y, Melchionna S, Habenstein B, Timr S, Chen J, Hnath B, Strodel B, Kayed R, Lesné S, Wei G, Sterpone F, Doig AJ, Derreumaux P.

Chem. Rev.121, 2545-2647 (2021)- DOI:10.1021/acs.chemrev.0c01122

Reproducibility Problems of Amyloid-β Self-Assembly and How to Deal with them

Faller, P. * Hureau, C.*

Front Chem., 8, 611227 (2021)- DOI: 10.3389/fchem.2020.611227

Extracellular Cu2+ pools and their detection: from current knowledge to next-generation probes

Falcone, E.*, Okafor, M. Vitale, N., Raibaut L., Sour, A, Faller P.*

Coord. Chem. Rev. 433 213727 (2021)- DOI: 10.1016/j.ccr.2020.213727

2020

Copper-binding motifs Xxx-His or Xxx-Zzz-His (ATCUN) linked to an antimicrobial peptide: Cu-binding, antimicrobial activity and ROS production

Bouraguba, Merwan; Glattard, Elise; Naude, Maxime; Pelletier, Remi; Aisenbrey, Christopher; Bechinger, Burkhard; Raibaut, Laurent; Lebrun, Vincent* and Faller, Peter*

Journal of Inorganic Biochemistry (2020), 213, 111255- DOI: 10.1016/j.jinorgbio.2020.111255

How trimerization of CTR1 N-terminal model peptides tunes Cu-binding
and redox-chemistry

Galler, Thibaut; Lebrun, Vincent; Raibaut, Laurent; Faller, Peter; Wezynfeld, Nina E*

Chemical Communications (2020), 56(81), 12194-12197- DOI: 10.1039/D0CC04693K

A terbium(iii) luminescent ATCUN-based peptide sensor for selective and reversible
detection of copper(ii) in biological media

Enrico Falcone, Paulina Gonzalez, Lucie Lorusso, Olivier Sénèque, Peter Faller*
and Laurent Raibaut*

Chemical communications (2020), 56 (35), 4797-4800. – DOI: 10.1039/D0CC01007C

The glutathione/metallothionein system challenges the design of
efficient O2-activating Cu-complexes

Santoro A, Calvo JS, Peris-Díaz MD, Krężel A, Meloni G, Faller P*

Angewandte Chemie (2020), 59(20), 7830-7835. – DOI: 10.1002/anie.201916316

2019

Acrolein and Copper as Competitive Effectors of α-Synuclein

HOT Paper

Falcone E, Ahmed IMM, Oliveri V, Bellia* F, Vileno B, El Khoury Y, Hellwig P, Faller P*, Vecchio G

Chemistry, 26(8), 1871-1879 (2019)- DOI: 10.1002/chem.201904885

Reversible turn-on fluorescent Cu(II) sensors: rather dream than reality?

(Dalton Transactions HOT articles)

Enrico Falcone, Angélique Sour, Vincent Lebrun, Gilles Ulrich, Laurent Raibaut* and Peter Faller*

Dalton Trans, 48, 14233-14237 (2019) – DOI: 10.1039/C9DT02864A

(Bio)Chemical strategies to modulate amyloid-βself-assembly

Ayala S, Genevaux P, Hureau C, Faller P.

ACS Chem Neurosci. 10, 3366-3374 (2019) – DOI: 10.1021/acschemneuro.9b00239

Switching on Endogenous Metal Binding Proteins in Parkinson’s Disease

Fleur A. McLeary, Alexandre N. Rcom-H’cheo-Gauthier, Michael Goulding,

Rowan A. W. Radford, Yuho Okita , Peter Faller, Roger S. Chung and Dean L. Pountney*

Cells. 8, E179, (2019) – DOI: 10.3390/cells8020179

Triggering Cu-coordination change in Cu(II)-Ala-His-His by external ligands

Paulina Gonzalez, Karolina Bossak-Ahmad, Bertrand Vileno, Nina E. Wezynfeld,
Youssef El Khoury, Petra Hellwig, Christelle Hureau,* Wojciech Bal* and Peter Faller*

Chem. Commun., 55, 8110-8113 (2019) – DOI: 10.1021/acs.inorgchem.9b00711

Copper-Targeting Approaches in Alzhzeimer’s Disease: How To Improve
the Fallouts obtained from in VItro Studies

Charlène Esmieu, Djamila Guettas, Amandine Conte-Daban, Laurent Sabater, Peter Faller, and Christelle Hureau*

Inorg. Chem., 58 (20), 13509-13527 (2019) – DOI: 10.1021/acs.inorgchem.9b00711

Role of PTA in the prevention of Cu(amyloid-β) induced ROS formation and amyloid-β oligomerisation in the presence of Zn

Elena Atrián-Blasco, Elena Cerrada, Peter Faller, Mariano Laguna and Christelle Hureau*

Metallomics, 11, 1154-1161 (2019) – DOI: 10.1021/acs.inorgchem.9b00711

Cu(II) Binding to the N-Terminal Model Peptide of the Human Ctr2 Transporter at
Lysosomal and Extracellular pH

Nina E. Wezynfeld,* Bertrand Vileno, and Peter Faller

Inorganic Chemistry, 58, 7488-7498 (2019) – DOI: 10.1021/acs.inorgchem.9b00711

Reactivity of Cu(II)-, Zn(II)-, and Fe(II)-thiosemicarbazone complexes with glutathione and metallothionein: from stability to dissociation to transmetallation

Alice Santoro, Bertrand Vileno, Òscar Palacios, Manuel David Peris-Díaz, Gilles Riegel, Christian Gaiddon, Artur Krężel and Peter Faller*

Metallomics, 11, 994-1004 (2019) – DOI: 10.1039/C9MT00061E

A Molecular Theranostic Agents for Photodynamic Therapy (PDT)
and Magnetic Resonance Imaging (MRI)

Sébastien Jenni, Angélique Sour*

Inorganics, 7(1), 10 (2019) – DOI: 10.1039/C8MT00274F

2018

The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(II)
from albumin. Implications for copper uptake by Ctr1

Ewelina Stefaniak, Dawid Płonka, Simon C. Drew, Karolina Bossak-Ahmad,
Kathryn L. Haas, M. Jake Pushie, Peter Faller, Nina E. Wezynfeld*, Wojciech Bal*

Metallomics, 10, 1723-1727 (2018) – DOI: 10.1039/C8MT00274F

Cu transfer from amyloid-β4–16 to metallothionein-3 : the role of the
neurotransmitter glutamate and metallothionein-3 Zn(II)-load states

Alice Santoro, Nina Ewa Wezynfeld, Ewelina Stefaniak, Adam Pomorski, Dawid Płonka,
Artur Krężel* Wojciech Bal*, Peter Faller*

Chem. Commun. 54, 12634-12637 (2018) – DOI: 10.1039/C8CC06221H

Low catalytic activity of the Cu(II)-binding motif (Xxx-Zzz-His; ATCUN) in reactive oxygen species production and inhibition by the Cu(I)-chelator BCS

Alice Santoro, Gulshan Walke, Bertrand Vileno, Prasad P. Kulkarni, Laurent Raibaut,
Peter Faller*

Chem. Commun. 54, 11945-11948 (2018) – DOI: 10.1039/C8CC06040A

Cu and Zn interaction with amyloid peptides: From fascinating chemistry to debated pathological relevance

Elena Atrián-Blasco, Paulina Gonzalez, Alice Santoro, Bruno Alies, Peter Faller, Christelle Hureau^*

Coord. Chem. Rev. 371, 38-55 (2018) – DOI: 10.1016/j.ccr.2018.04.007

Burning Amyloid-β with a Near-Infrared Photosensitizer

Lebrun, V. & Faller. P. (Preview, not peer reviewed)

CHEM, 4, 663–665 (2018) – DOI: 10.1016/j.chempr.2018.03.019

Ascorbate oxidation by Cu(Amyloid-β) complexes: determination of the intrinsic rate as function of alterations in the peptide sequence reveals key residues for ROS production

Atrián-Blasco E, Del Barrio M, Faller P.* Hureau C.*

Anal Chem. 90, 5909-5915 (2018) – DOI: 10.1021/acs.analchem.8b00740

N-terminal Cu Binding Motifs Xxx-Zzz-His (ATCUN) and Xxx-His and their derivatives: Chemistry, Biology and Medicinal Applications

Gonzalez P, Bossak K, Stefaniak E, Hureau C, Raibaut L, Bal W.*, Faller, P.*

Chem. Eur. J. 24, 8029-8041 (2018) – DOI: 10.1002/chem.201705398

Aβ/drug interactions from computer simulations and cell-based assays

Nguyen PH, Del Castillo-Frias MP, Berthoumieux O, Faller P, Doig AJ, Derreumaux P.*

J Alzheimers Dis. – DOI: 10.3233/JAD-179902.(2018)

2017

Cu(II)-binding to the peptide Ala-His-His, a chimera of the canonical Cu(II)-binding motifs Xxx-His and Xxx-Zzz-His (ATCUN)

Gonzalez P, Vileno B, Bossak K, El Khoury Y, Hellwig P, Bal W, Hureau C*, Faller P.*

Inorg. Chem. 56, 14870-14879 (2017) – DOI: 10.1021/acs.inorgchem.7b01996

Chemistry of Mammalian Metallothioneins and their Interaction with Amyloidogenic Peptides and Proteins

Atrián-Blasco E, Santoro A, Pountney DL, Meloni G, Hureau C, Faller P.*

Chem. Soc. Rev., 46, 7683-7693 (2017) – DOI: 10.1039/c7cs00448f

Oxidative stress and the amyloid beta peptide in Alzheimer’s Disease

Cheignon C, Tomas M, Bonnefont-Rousselot D, Faller P, Hureau C, Collin F.*

Redox Biology, 14, 450-464 (2018) – DOI: 10.1016/j.redox.2017.10.014

Cysteine and Glutathione trigger the Cu-Zn swap between Cu(II)-Amyloid-β4-16 peptide and Zn7-Metallothionein-3

Santoro A, Wezynfeld N. E., Vašák M, Bal W, Faller P.*

Chem. Comm., 53, 11634-11637 (2017) – DOI: 10.1039/c7cc06802f

Why Is Research on Amyloid-β Failing to Give New Drugs for Alzheimer’s Disease? (Viewpoint)

Doig AJ, Del Castillo-Frias MP, Berthoumieu O, Tarus B, Nasica-Labouze J, Sterpone F, Nguyen PH, Hooper NM, Faller P, Derreumaux P.

ACS Chem Neurosci. ACS, 8, 1435-1437 (2017) – DOI: 10.1021/acschemneuro.7b00188

Identification of key structural features of the elusive Cu-Aβ complex generating ROS in Alzheimer’s Disease

Cheignon C, Jones M, Atrián-Blasco E, Kieffer I, Faller P, Collin F, Hureau C.*

Chemical Science, 8, 5107-5118 (2017) – DOI: 10.1039/c7sc00809k

Similarities and differences of copper and zinc cations binding to biological relevant peptides studied by vibrational spectroscopies

Schirer A, El Khoury Y, Faller P, Hellwig P.*

Biol. Inorg. Chem, 22, 581-589 (2017) – DOI: 10.1007/s00775-017-1449-0

Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies

Okita Y, Rcom-H’cheo-Gauthier AN, Goulding M, Chung RS, Faller P, Pountney DL.*

Front Neurosci. Apr 4;11:114. – DOI: 10.3389/fnins.2017.00114